Direct decarboxylative Giese reactions
Traditionally, Giese reactions depended upon toxic tin hydride reagents (e.g., 5 in Scheme 2A) with alkyl halides or selenides as radical precursors (6), together with an initiation source in the form of light, heat or a radical initiator (e.g., AIBN) (). 3 Upon initiation, a tin radical (III) is generated which undergoes X-atom transfer with the radical precursor 6 to produce …